Inhibitor of Transcription .
The synthesis of RNA is inhibit by certain antibiotics and toxins.
Actinomycin D : this is also known as dactinomycin , it is synthesized by streptomyes . actinomycin D binds with DNA template strand and blocks the movement of RNA polymerases. This was the first antibiotic use for the treatment of tumors.
Rifampin : It is an antibiotic widely use for the treatment of tuberculosis and leprosy. Rifampin binds with the B-subunit of prokaryotic RNA polymerases and inhibit its activity.
A-Amanitin: it is a toxin produced by mushroom, amanita phalloides. This mushroom is delicious in taste but poisonous. Due to the toxin a amanitin which tightly bind with RNA polymerases ii of eukaryotes and inhibits transcription
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